Depakote--preventive treatment of migraine headache symptoms
Depakote (divalproex sodium). The migraine dose is 250-500mg/2 times a day. Depakote ER 500-1000 mg may be taken as one dose at night.
Depakote has an FDA indication for treating epilepsy, bipolar disorder, and migraine.
Side effects: drowsiness, nausea, somnolence, hair loss, tremor, weight gain, fetal/liver abnormalities.
Depakote can be a useful single preventive drug if the patient has both migraine and epilepsy, or migraine and bipolar disorder.
The FDA has said that Depakote is a Class X risk for causing severe fetal malformations in pregnant women. Therefore, the International Epilepsy Depakote should never be given to potentially fertile women.